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A novel and significant dimension illuminated by our study is SIRT1’s pivotal role in lipid metabolic homeostasis under DOX challenge ( As a key metabolic regulator, SIRT1 modulates the transcriptional activity of multiple transcription factors and coactivators involved in lipid metabolism through deacetylation, participating in fatty acid oxidation, lipogenesis, and cholesterol metabolism, thereby maintaining lipid metabolic homeostasis in tissues and organs ( de novo synthesis of fatty acids and triglycerides ( Arctiin, like many natural compounds, likely exerts its biological effects through interactions with multiple cellular targets